ノルエピネフリン欠乏症のよだれ治療

化学物質とホルモンの両方として医学的に分類されるノルエピネフリンは、私たちの体のエネルギーを代謝するために重要です。ノルエピネフリンが不十分であるため、さまざまな健康問題が生じます。まれに重度の欠陥のある場合、人は弱くなり、心臓のトラブルから時折のよだれに至るまでの症状で衰弱します。

1. ノルエピネフリン欠乏症

   • Mutations of the dopamine beta-hydroxylase gene are responsible for norepinephrine deficiency---also called dopamine beta-hydroxylase deficiency. DBH deficiency is defined in the Orphanet Journal of Rare Diseases as "a complete absence of noradrenaline and adrenaline in plasma together with increased plasma dopamine levels."
     The results include overall weakness, limb rigidity, droopy eyelids, severe low blood pressure, stuffy nose, poor muscle tone, chronic low blood sugar, infant hypothermia, ejaculation problems, exercise intolerance and---occasionally弱体化した状態で---よだれを垂らしている。

   治療

   • 一部の医師は、電解質、ミネラル吸収、液レベルのバランスをとるのに役立つミネラルコルチコイドを試しています。 Along with these, doctors may use adrenergic receptor agonists, which in essence may replace norepinephrine in the important role of activating contraction of arteriolar muscles and relaxation of bronchial muscles.
     But the most promising while still controversial treatment is L-threo-3, 4-dihydroxyphenylserine, more commonly called DOPS. French clinical researchers Jean-Michel Senard and Philippe Rouet report in their 2006 article in the Orphanet Journal of Rare Diseases that DOPS can reverse plasma noradrenaline levels to normal and can reverse many of the behavioral effects of DBH deficiency. The reversal may include drooling for patients experiencing this effect.
     Senard and Rouet's studies in humans found that most specifically, DOPS can increase blood pressure and relieve postural symptoms.

   正しいヘルプを取得する

   • DBH欠乏症は非常にまれであり、科学者や医師がまだ理解していないことがたくさんあります。 There is no singular cure, and no medication addresses all of the complications and system failures associated with the condition.
     Addressing a DBH-deficient patient's drooling issue is most likely accomplished through treatments which address an entire scope of issues such as rigidity or fluid balance. If you or a loved one is experiencing DBH deficiency, it's advisable to seek out a specialist on this rare genetic disorder.
     Since no two cases are exactly the same, the specialist will tailor treatments specific to a patient's needs.